Maybe the save game issue discussed here is part of my issue but after a few hours of game play the mission seems to break around the car bomb mission. In one play through I was able to do the mission but the saves corrupted so I started new. The next time through I received the car bomb mission, went to start it but it would let me. Left the area to head to a safe house thinking a fast travel might kick something loose, only to discover I couldn’t fast travel. All NPCs in the mission were gone, known roadblocks were gone as well as any placed objects for the mission. Saved the game by “Exit and Save”, loaded back in without an issue but the mission was still in the same state.