The landing procedure is somewhat unreliable, the autopilot will sometimes go at crawl speed, or the skycrane will go completely apeshit and pancake into the ground.
The rock radiation analysis is very fiddly, i've had to turn around rocks more often than not to get it to register that it was at the right distance (even when it's touching).
Probes slide on slopes, and when they do they take off again and try to land again, it will sometimes happen because your probe arm lifted the probe a little bit off the ground.
Due to the previous point some probe photos are impossible to take without another probe.
Some of the "rock formations" photos seems impossible to take, both crosses are green but the rectangle will not light up.
The game tend to crash after an objective has been validated, the kind that brings a mission completion dialog especially.
Solar panels sometimes stop producing power when the rover isn't moving, which drains the chemical battery if you are manipulating the arm for example.