If you have a Logitech mouse, you might want to try this out:
Press Ctrl + Alt + Del to open Task manager.
Close the process EM_EXEC.EXE.
This is the special Logitech MouseWare driver. Don't worry, your mouse will work without it too. It just adds some extra functionality to your mouse like redefining button actions and such.
Then start OFP as usual.
This has helped me many times. For some strange reason, it has some issues with a few applications. The result is extremely slow mouse movements.
I can't remember having had problems with OFP, though.
You may, to avoid having to shut the process down evey time you want to play OFP, try installing MouseWare version 9.73. This doesn't seem to have these problems.
Good luck.