I have the same problem, only with resistance.
(That is CTD @ new multiplayer game or editor, campaign seems to work)
System is an Athlon 1.1, ECS Elitegroup SiS Mainboard with onboard sound, GF2MX 32mb (no brand), WinXP Pro.
Tried disabling hardware acceleration with sound to no avail. Not quite prepared to try nuking ACPI yet, but it's getting to that. Might be time for a reformat anyway. Grr.
Oh yeah, no addons - fresh OFP install.
Trying aperture stuff now...